When the cross is mentioned in the Bible, it most often does not refer to a physical wooden cross, except when specifically describing Jesus’ crucifixion on Calvary. “Taking up your cross” refers to the metaphorical cross that Jesus’ speaks about in Luke 9:23. “Taking up your cross” is the act of denying the sinful thoughts that come up in you and putting them to death. Colossians 3:5. Galatians 5:24.